Checks and Balances—The Limits of ß-Cell Endurance to ER Stress

Decio L. Eizirik and Alexandra Coomans de Brachène, Diabetes 2017;66:1–3 

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Protective role of complement C3 against cytokine-mediated β-cell apoptosis

Reinaldo S. Dos Santos, Laura Marroqui, Fabio A. Grieco, Lorella Marselli, Mara

Suleiman, Stefan R. Henz, Piero Marchetti, Rasmus Wernersson, Decio L. Eizirik. Endocrinology 2017-00104

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Guanabenz sensitizes pancreatic β cells to lipotoxic endoplasmic reticulum stress and apoptosis

Baroj Abdulkarim, Miriam Hernangomez, Mariana Igoillo Esteve, Daniel A Cunha, Lorella

Marselli, Piero Marchetti, Laurence Ladriere, Miriam Cnop. Endocrinology 2016-1773

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Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes

Piero Marchetti, Marco Bugliani, Vincenzo De Tata, Mara Suleiman1 and Lorella Marselli

Front. Cell Dev. Biol., 23 May 2017

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MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic ß-Cells.

Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu,1 Olatz Villate, Laura Marroqui,1 Laurence Ladrière,  Ksenya Tugay, Romano Regazzi,

Marco Bugliani, Piero Marchetti, Francesco Dotta, and Décio L. Eizirik. Diabetes 2017;66:100–112

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Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival

Jonàs Juan-Mateu, Tatiana H. Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, Jean-Valery Turatsinze, Letícia A. Brondani, Tarlliza R. Nardelli, Tatiane C. Nogueira, Jonathan L. S. Esguerra, Maria Inês Alvelos, Piero Marchetti, Lena Eliasson, and Décio L. Eizirik. 

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 292, NO. 8, pp. 3466–3480, February 24, 2017     DOI 10.1074/jbc.M116.748335

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Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes.

Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck,  Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik 

Diabetologia (2017) 60:656–667      DOI 10.1007/s00125-016-4201-3

 

Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes Masini M, Marselli L, Himpe E, Martino L, Bugliani M, et al.(2017). PLOS ONE 12(6): e0179398. 

 

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.

Seung-Hee Lee, Daniel Cunha, Carlo Piermarocchi, Giovanni Paternostro, Anthony Pinkerton, Laurence Ladriere, Piero Marchetti, Decio L. Eizirik, Miriam Cnop, Fred Levine.

Biochemical Pharmacology (2017) 138, 140-149.https://doi.org/10.1016/j.bcp.2017.05.007

 

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

Marroqui, L., Dos Santos, R.S., Op de beeck, A. et al. 

Diabetologia (2017) 60: 656. 

 

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, LauraMarroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, MarcoBugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik

Diabetes Jan 2017, 66 (1) 100-112; DOI: 10.2337/db16-0592

 

Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival 

Jonàs Juan-Mateu, Tatiana H. Rech, Olatz Villate, Esther Lizarraga-Mollinedo, Anna Wendt, Jean-Valery Turatsinze, Letícia A. Brondani, Tarlliza R. Nardelli, Tatiane C. Nogueira, Jonathan L. S. Esguerra, Maria Inês Alvelos, Piero Marchetti, Lena Eliasson, and Décio L. Eizirik

J. Biol. Chem. 2017 292: 3466-. doi:10.1074/jbc.M116.748335

 

High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus 

Anette P. Gjesing, Gao Rui, Jeannet Lauenborg, Christian Theil Have, Mette Hollensted, Ehm Andersson, Niels Grarup, Jihua Sun, Shi Quan, Ivan Brandslund, Peter Damm, Oluf Pedersen, Jun Wang, Torben Hansen;, 

Journal of the Endocrine Society, Volume 1, Issue 6, 1 June 2017, Pages 681–690, 

 

Human pancreatic B cell IncRNAs control cell-specific regulatory networks.

Ildem Akerman,Zhidong Tu,Anthony Beucher,Delphine M.Y. Rolando,Claire Sauty-Colace,Marion Benazra,Nikolina Nakic,Jialiang Yang,Huan Wang,Lorenzo Pasquali,Ignasi Moran,Javier Garcia-Hurtado,Natalia Castro,Roser Gonzalez-Franco,Andrew F. Stewart,Caroline Bonner,Lorenzo Piemonti,Thierry Berney,Leif GroopJulie Kerr-Conte,Francois Pattou,Carmen Argmann,Eric Schadt,Philippe Ravassard,and Jorge Ferrer

Cell Metabolism (2017)25, 400–411 
 

 

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes.

Tania Quesada-López,Rubén Cereijo, Jean-Valery Turatsinze, Anna Planavila, Montserrat Cairó, Aleix Gavaldà-Navarro, Marion Peyrou, Ricardo Moure, Roser Iglesias, Marta Giralt, Decio L. Eizirik & Francesc Villarroya

Nature communications (2016) 7, 13479

 

Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).

Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, and Miriam Cnop

 J. Biol. Chem. 2017 292: 14977-. doi:10.1074/jbc.M116.769877

 

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea

Molecular Metabolism 6, 2017, 1024-1039

 

Heterozygous RFX6protein truncating variants are associated with MODY with reduced penetrance.

Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W. Laver, Kevin Colclough, Matthew B. Johnson, Marc Abramowicz, Leif Groop, Päivi J. Miettinen, Maggie H. Shepherd, Sarah E. Flanagan, Sian Ellard, Nobuya Inagaki, Andrew T. Hattersley, Tiinamaija Tuomi, Miriam Cnop & Michael N. Weedon.

Nature Communications (2017) 8, 888

 

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal Beta cells and human pancreatic islets.

Federica Ciregia, Marco Bugliani, Maurizio Ronci, Laura Giusti, Claudia Boldrini, Maria R Mazzoni, Sandra Mossuto, Francesca Grano, Miriam Cnop, Lorella Marselli, Gino Giannaccini, Andrea Urbani, Antonio Lucacchini & Piero Marchetti

Nature Scientific Reports (2017) 7, 13445

 

Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, and Decio L. Eizirik

The FASEB Journal 2018 32:3, 1524-1536 

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Europe has to step up its efforts to produce innovative and sage diabetes technology.

Miriam CnopEmail authorTomasz KlupaNikolaos TentolourisAnna NovialsRémy BurcelinMischa van Eimeren

Diabetologia (2017) 60, 2532-2533

 

CXCL14, brown adipokine that mediates brown-fat-to-macrophage communication in thermogenic adaption.

Rubén Cereijo, Aleix Gavaldà-Navarr, Montserrat Cairó, Tania Quesada-López, Joan Villarroya, Samantha Morón-Ros, David Sánchez-Infantes, Marion Peyrou, Roser Iglesias, Teresa Mampel, Jean-Valery Turatsinze, Décio L. Eizirik, Marta Giralt, Francesc Villarroya

Cell Metabolism (2018) 28, 750-763

 

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Demine, Stéphane, Balhuizen, Alexander, Debaille, Vinciane, Joosten, Lieke, Fereau, Maïté, Chilla, Satya, Millard, Isabelle, Scharfmann, Raphaël, Egrise, Dominique, Goldman, Serge, Marchetti, Piero, Gotthardt, Martin, Laurent, Sophie, Burtea, Carmen, Eizirik, Decio

Molecules (2018) 23, 2100

 

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses.

Line Engelbrechtsen, Yuvaraj Mahendran†, Anna Jonsson, Anette Prior Gjesing, Peter E. Weeke, Marit E. Jørgensen, Kristine Færch, Daniel R. Witte, Jens J. Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K. Kanters and Torben Hansen

BMC Genetics (2018) 19, 15    

 

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Benoît Hastoy, Mahdieh Godazgar, Anne Clark, Vibe Nylander, Ioannis Spiliotis, Martijn van de Bunt, Margarita V. Chibalina, Amy Barrett, Carla Burrows, Andrei I. Tarasov, Raphael Scharfmann, Anna L. Gloyn & Patrik Rorsman

Nature Scientific Reports (2018) 8, 16994